TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2650.
Locate Jan Aushadhi KendraClinical Overview
Tranylcypromine is a non-hydrazine, irreversible, non-selective monoamine oxidase inhibitor (MAOI). It binds and covalently inactivates both MAO-A and MAO-B enzymes, preventing the metabolic breakdown of norepinephrine, serotonin, and dopamine throughout the central nervous system. Reserved for severe, treatment-resistant major depression refractory to other classes.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally in divided doses with water, usually morning and midday, avoiding evening doses to prevent insomnia. Patients must strictly adhere to a tyramine-free diet during therapy and for 2 weeks after stopping.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Orthostatic hypotension, insomnia, dry mouth, dizziness, weight gain, sexual dysfunction. Rare/Severe: Boxed warning: Hypertensive crisis ("cheese reaction" characterized by occipital headache, severe hypertension, intracranial hemorrhage) triggered by tyramine-rich foods or sympathomimetic drugs, and serotonin syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Hypertensive crisis. Absolute restriction on tyramine-containing foods (aged cheeses, draft beer, red wine, cured meats, fermented soy products). Strictly contraindicated with sympathomimetics, other antidepressants, opioids (pethidine), and dextromethorphan.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.