Tranylcypromine

Active pharmaceutical substance formulated in Jan Aushadhi generic products for CNS, Nerve & Mental Health treatment.

🧴 Clinical Application

Take orally in divided doses with water, usually morning and midday, avoiding evening doses to prevent insomnia. Patients must strictly adhere to a tyramine-free diet during therapy and for 2 weeks after stopping.

⚠️ Side Effects

Common: Orthostatic hypotension, insomnia, dry mouth, dizziness, weight gain, sexual dysfunction. Rare/Severe: Boxed warning: Hypertensive crisis ("cheese reaction" characterized by occipital headache, severe hypertension, intracranial hemorrhage) triggered by tyramine-rich foods or sympathomimetic drugs, and serotonin syndrome.

🛡️ Safety Warnings

Black box warning: Hypertensive crisis. Absolute restriction on tyramine-containing foods (aged cheeses, draft beer, red wine, cured meats, fermented soy products). Strictly contraindicated with sympathomimetics, other antidepressants, opioids (pethidine), and dextromethorphan.