TabletsClinical Overview
Iguratimod Tablets (25mg) is a novel synthetic small-molecule disease-modifying antirheumatic drug (DMARD). It selectively suppresses the nuclear translocation of NF-kappa-B, downregulating the transcription of pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha) and directly inhibiting immunoglobulin (IgG, IgM) synthesis by B-cells without suppressing bone marrow hematopoiesis. Concurrently, it promotes osteoblast differentiation and inhibits osteoclastogenesis by suppressing RANKL. Indicated for active Rheumatoid Arthritis refractory or intolerant to methotrexate.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 25 mg twice daily (or 25 mg once daily initial) after meals with a glass of water. Swallow whole.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Transaminase elevations, abdominal pain, nausea, peptic discomfort, rash. Rare/Severe: Severe hepatic injury, gastrointestinal ulceration, and agranulocytosis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in pregnancy and nursing mothers. Regularly monitor liver enzymes and complete blood counts every 4 weeks. Exercise caution when combined with other hepatotoxic DMARDs.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.