TabletsClinical Overview
Vortioxetine is a multimodal serotonergic antidepressant (SMS). It acts as a selective serotonin reuptake inhibitor (SERT inhibition) combined with direct agonist activity at 5-HT1A receptors, partial agonism at 5-HT1B, and antagonist activity at 5-HT1D, 5-HT3, and 5-HT7 receptors. This multimodal receptor profile enhances acetylcholine, noradrenaline, and histamine release, demonstrating notable benefits on depressive cognitive dysfunction. Indicated for major depressive disorder (MDD).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily with or without food, swallowed with water. May be taken morning or evening. Titrate as directed. When discontinuing 15 mg or 20 mg doses, reduce to 10 mg for one week before stopping to avoid discontinuation symptoms.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea (most frequent, usually transient), vomiting, constipation, diarrhea, dizziness, abnormal dreams, pruritus. Rare/Severe: Suicidal ideation, serotonin syndrome, bleeding complications, and hyponatremia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality in children and young adults. Contraindicated with MAO inhibitors. Co-administration with strong CYP2D6 inhibitors (bupropion, fluoxetine) requires dose reduction by half.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Vortioxetine Tablets 10mg
Vortioxetine is a multimodal serotonergic antidepressant (SMS). It acts as a selective serotonin reuptake inhibitor (SERT inhibition) combined with direct agonist activity at 5-HT1A receptors, partial agonism at 5-HT1B, and antagonist activity at 5-HT1D, 5-HT3, and 5-HT7 receptors. This multimodal receptor profile enhances acetylcholine, noradrenaline, and histamine release, demonstrating notable benefits on depressive cognitive dysfunction. Indicated for major depressive disorder (MDD).
Vortioxetine Tablets 5mg
Vortioxetine is a multimodal serotonergic antidepressant (SMS). It acts as a selective serotonin reuptake inhibitor (SERT inhibition) combined with direct agonist activity at 5-HT1A receptors, partial agonism at 5-HT1B, and antagonist activity at 5-HT1D, 5-HT3, and 5-HT7 receptors. This multimodal receptor profile enhances acetylcholine, noradrenaline, and histamine release, demonstrating notable benefits on depressive cognitive dysfunction. Indicated for major depressive disorder (MDD).