TabletsClinical Overview
Topiroxostat Tablets (20mg, 40mg, 60mg) is a novel non-purine selective xanthine oxidoreductase (XOR) inhibitor on the PMBI formulary. It inhibits both the xanthine dehydrogenase and xanthine oxidase forms of the enzyme by interacting with multiple amino acid residues in the solvent-accessible channel, reducing uric acid production and oxidative stress with exceptional renal safety. Indicated for hyperuricemia with or without gout in patients with chronic kidney disease (CKD stage 3).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 20 mg twice daily with water, titrated up to 40 mg to 60 mg twice daily based on serum uric acid target (<6.0 mg/dL). Can be taken with or without food.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Initial gout flares, transaminase elevations, mild dizziness, gastrointestinal discomfort. Rare/Severe: Severe allergic reactions and cardiovascular events.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Co-administer prophylactic anti-gout therapy during initial months. Contraindicated with azathioprine or mercaptopurine. Safe in moderate chronic kidney disease.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Topiroxostat Tablets 20mg
Topiroxostat Tablets (20mg, 40mg, 60mg) is a novel non-purine selective xanthine oxidoreductase (XOR) inhibitor on the PMBI formulary. It inhibits both the xanthine dehydrogenase and xanthine oxidase forms of the enzyme by interacting with multiple amino acid residues in the solvent-accessible channel, reducing uric acid production and oxidative stress with exceptional renal safety. Indicated for hyperuricemia with or without gout in patients with chronic kidney disease (CKD stage 3).
Topiroxostat Tablets 60mg
Topiroxostat Tablets (20mg, 40mg, 60mg) is a novel non-purine selective xanthine oxidoreductase (XOR) inhibitor on the PMBI formulary. It inhibits both the xanthine dehydrogenase and xanthine oxidase forms of the enzyme by interacting with multiple amino acid residues in the solvent-accessible channel, reducing uric acid production and oxidative stress with exceptional renal safety. Indicated for hyperuricemia with or without gout in patients with chronic kidney disease (CKD stage 3).