CapsulesClinical Overview
Flupirtine Maleate Capsules (100mg) is a non-opioid, non-NSAID centrally acting analgesic functioning as a Selective Neuronal Potassium Channel Opener (SNEPCO). It opens voltage-gated Kv7 (KCNQ) potassium channels, hyperpolarizing the neuronal membrane and stabilizing resting membrane potential. This indirectly blocks NMDA glutamate receptors, dampening central pain sensitization, and acts as a central muscle relaxant without causing gastric ulceration or opioid-like respiratory depression. Indicated for acute moderate-to-severe pain, acute musculoskeletal pain, tension headaches, and painful muscle spasms.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 100 mg three to four times daily with a full glass of water, with or without food. Maximum duration: strictly limit continuous therapy to under 2 weeks. Weekly liver function testing (LFTs) is mandatory if therapy extends beyond a few days.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, dizziness, fatigue, dry mouth, nausea, heartburn, green discoloration of urine. Rare/Severe: Severe, potentially fatal drug-induced liver injury (DILI / acute liver failure).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Severe drug-induced hepatotoxicity; strictly contraindicated in patients with pre-existing liver disease. Treatment duration must NEVER exceed 2 weeks. Monitor liver enzymes at baseline and weekly; discontinue immediately if transaminases rise or signs of hepatitis (jaundice, pruritus, dark urine) emerge.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.