TabletsClinical Overview
Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Swallow whole with a full glass of water, with or without meals. Do not chew, crush, or open capsules to sprinkle pellets, as acid exposure inactivates the medication. Do not discontinue abruptly; taper gradually.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dry mouth, somnolence, constipation, insomnia, dizziness, fatigue, diaphoresis. Rare/Severe: Boxed warning: Suicidal ideation; hepatotoxicity/hepatic failure, orthostatic hypotension, serotonin syndrome, and urinary retention.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality in young adults. Contraindicated in patients with hepatic impairment, severe renal impairment (CrCl < 30 mL/min), or uncontrolled narrow-angle glaucoma. Monitor blood pressure and liver enzymes regularly. Avoid heavy alcohol use.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Duloxetine Gastro-resistant Tablets 20 mg
Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Pregabalin 75mg + Duloxetin (Delayed Release) 30mg Capsules
Pregabalin and Duloxetine is a synergistic dual-mechanism neuro-analgesic formulation. Pregabalin reduces presynaptic excitatory neurotransmitter release by modulating neuronal voltage-gated calcium channels, while duloxetine, a potent serotonin and noradrenaline reuptake inhibitor (SNRI), amplifies descending central monoaminergic inhibitory pain pathways. Indicated for refractory peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Pregabalin 75mg + Duloxetin (Delayed Release) 20mg Capsules
Pregabalin and Duloxetine is a synergistic dual-mechanism neuro-analgesic formulation. Pregabalin reduces presynaptic excitatory neurotransmitter release by modulating neuronal voltage-gated calcium channels, while duloxetine, a potent serotonin and noradrenaline reuptake inhibitor (SNRI), amplifies descending central monoaminergic inhibitory pain pathways. Indicated for refractory peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Pregabalin 50mg + Duloxetin (Delayed Release) 20mg Capsules
Pregabalin and Duloxetine is a synergistic dual-mechanism neuro-analgesic formulation. Pregabalin reduces presynaptic excitatory neurotransmitter release by modulating neuronal voltage-gated calcium channels, while duloxetine, a potent serotonin and noradrenaline reuptake inhibitor (SNRI), amplifies descending central monoaminergic inhibitory pain pathways. Indicated for refractory peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.