CapsulesClinical Overview
Pregabalin and Duloxetine is a synergistic dual-mechanism neuro-analgesic formulation. Pregabalin reduces presynaptic excitatory neurotransmitter release by modulating neuronal voltage-gated calcium channels, while duloxetine, a potent serotonin and noradrenaline reuptake inhibitor (SNRI), amplifies descending central monoaminergic inhibitory pain pathways. Indicated for refractory peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Swallow capsule whole with water; do not crush or chew delayed-release pellets. May be taken with or without food. Take consistently at the same time each day. Never abruptly discontinue therapy due to risk of withdrawal syndrome.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dizziness, somnolence, nausea, dry mouth, constipation, fatigue, hyperhidrosis. Rare/Severe: Suicidal thoughts in young adults, serotonin syndrome, acute angle-closure glaucoma, hepatotoxicity, and hyponatremia/SIADH.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for antidepressant-related suicidality in young patients. Contraindicated in uncontrolled narrow-angle glaucoma and concurrent MAOIs. Monitor blood pressure and liver enzymes periodically. Avoid alcohol.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Pregabalin Capsules 75 mg
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Pregabalin 75mg + Methylcobalamin 750mcg Tablets
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Pregabalin Tablets 75 mg
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Duloxetine Gastro-resistant Tablets 20 mg
Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.