TabletsClinical Overview
Solifenacin Succinate Tablets (5mg, 10mg) is a competitive, selective muscarinic M3 receptor antagonist on the WHO Model List framework for Overactive Bladder. It exhibits higher affinity for muscarinic M3 receptors over M1 and M2 subtypes, specifically blocking parasympathetic acetylcholine transmission in the bladder detrusor muscle to suppress involuntary detrusor contractions and increase bladder compliance and volume to first micturition. Indicated for symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency in Overactive Bladder syndrome.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily, starting at 5 mg and titrating to 10 mg if needed, with liquids. Swallow the tablet whole; can be taken with or without food. Do not chew or crush. In severe renal impairment (CrCl < 30 mL/min) or moderate hepatic impairment, maximum dose is 5 mg daily.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth (xerostomia), constipation, blurred vision, dyspepsia, nausea, dry eyes. Rare/Severe: Acute urinary retention, QTc prolongation, angioedema, and paralytic ileus.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in urinary retention, severe gastrointestinal conditions (toxic megacolon), myasthenia gravis, and uncontrolled narrow-angle glaucoma. Monitor for heat exhaustion during hot weather due to decreased sweating.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, nephrological diagnosis, or urological treatment recommendations. Always consult a registered nephrologist, urologist, or qualified medical practitioner before initiating, modifying, or discontinuing any kidney or urinary tract medication.