TabletsClinical Overview
Nicorandil is a dual-action antianginal agent possessing both ATP-sensitive potassium channel (K_ATP) opening and nitrate-like vasodilating properties. By opening sarcolemmal K_ATP channels, it hyperpolarizes vascular smooth muscle membranes, dilating coronary arterioles and reducing cardiac afterload, while its nitrate moiety stimulates guanylate cyclase to dilate systemic veins and reduce preload. Also provides cardioprotective ischemic preconditioning. Indicated for the prevention and long-term treatment of chronic stable angina pectoris.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, divided twice daily (morning and evening), with or without meals. Swallow whole; do not chew or crush. Follow prescribed schedule.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Severe headache (especially at initiation), dizziness, nausea, vomiting, flushing, weakness. Rare/Severe: Severe, refractory ulceration of the gastrointestinal tract, skin, and mucosal tissues (anal, oral, perianal ulcers, and gastrointestinal perforation); severe hypotension.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Major safety warning: Can cause serious gastrointestinal and mucosal ulcerations (oral, peristomal, anal ulcers, diverticular perforation); discontinue immediately if persistent ulceration develops. Absolute contraindication with PDE-5 inhibitors (sildenafil, tadalafil). Contraindicated in cardiogenic shock, severe hypotension, and acute pulmonary edema.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified cardiologist/pharmacist before initiating, altering, or substituting any cardiovascular medication.