CapsulesClinical Overview
Indomethacin Capsules (25mg) is a methylated indole derivative NSAID on the WHO Model List of Essential Medicines. It is one of the most potent non-selective cyclooxygenase (COX-1/COX-2) inhibitors available, powerfully suppressing prostaglandin synthesis, inhibiting leukocyte motility, and reducing cerebral blood flow. Indicated for acute gouty arthritis, ankylosing spondylitis, severe osteoarthritis, acute bursitis/tendinitis, and paroxysmal hemicrania / hemicrania continua (indomethacin-responsive headaches).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 25 mg to 50 mg two to three times daily strictly with food, milk, or an antacid with a full glass of water to reduce severe gastrointestinal distress. Acute gout: 50 mg three times daily until pain subsides, then taper rapidly.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Frontal throbbing headache (occurs in up to 25-50% of patients), dizziness, lightheadedness, severe dyspepsia, nausea, confusion, depression. Rare/Severe: Severe gastrointestinal ulceration/perforation, acute renal failure, corneal deposits, and retinal disturbances.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Severe GI toxicity and CV thrombotic risk. High frequency of central nervous system adverse effects (severe frontal headache, dizziness, confusion); caution in elderly and psychiatric patients. Contraindicated in active peptic ulcer disease, CABG surgery, and severe renal failure.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.