InjectionClinical Overview
Docetaxel Injection (80mg, 120mg) is a semi-synthetic taxane antineoplastic on the WHO Model List of Essential Medicines. It binds to free tubulin and stabilizes microtubule bundles, inhibiting mitotic spindle dissolution with approximately double the tubulin-binding affinity of paclitaxel. Indicated for locally advanced or metastatic breast cancer, non-small cell lung cancer, hormone-refractory metastatic prostate cancer (with prednisone), gastric adenocarcinoma, and squamous cell carcinoma of the head and neck.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer intravenously only over 1 hour diluted in 0.9% NaCl or 5% Dextrose. MANDATORY PREMEDICATION: Dexamethasone 8 mg orally twice daily for 3 consecutive days, starting the day prior to docetaxel administration, to mitigate severe fluid retention and hypersensitivity reactions.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Complete alopecia, neutropenia (nadir day 7), fatigue, asthenia, stomatitis, onycholysis (nail dystrophy and hyperpigmentation). Rare/Severe: Severe fluid retention / third-spacing (pleural effusion, ascites, generalized peripheral edema), fatal enterocolitis/neutropenic typhlitis, and severe hypersensitivity.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Treatment-related mortality in patients with abnormal liver function; contraindicated in patients with bilirubin > ULN or AST/ALT > 1.5× ULN with alkaline phosphatase > 2.5× ULN. Black Box Warning: Severe neutropenia. Black Box Warning: Severe fluid retention; mandatory 3-day oral corticosteroid premedication is essential.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, oncological diagnosis, or chemotherapy protocol guidance. Cancer therapies require specialized administration under the direct supervision of a registered medical oncologist in an accredited healthcare facility.