TabletsClinical Overview
Clomipramine Hydrochloride is a chlorinated tricyclic antidepressant with exceptionally potent and selective serotonin reuptake inhibition compared to other TCAs. Its demethylated metabolite acts as a norepinephrine reuptake inhibitor. Considered the gold-standard pharmacological agent for severe obsessive-compulsive disorder (OCD). Also indicated for treatment-resistant depression, panic disorder, and cataplexy associated with narcolepsy.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with food to reduce gastric irritation, with the largest portion taken at bedtime. Sustained-release formulations must be swallowed whole without chewing or crushing. Taper slowly when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth, constipation, somnolence, dizziness, tremor, sweating, sexual dysfunction, weight gain. Rare/Severe: High seizure risk (dose-dependent), cardiac arrhythmias, paralytic ileus, hyperthermia, and suicidality.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality. Highest seizure incidence among classical antidepressants; avoid high doses (> 250 mg/day) and use caution in patients with lowered seizure thresholds. Contraindicated with MAOIs and post-MI.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Clomipramine Hydrochloride Tablets 10mg
Clomipramine Hydrochloride is a chlorinated tricyclic antidepressant with exceptionally potent and selective serotonin reuptake inhibition compared to other TCAs. Its demethylated metabolite acts as a norepinephrine reuptake inhibitor. Considered the gold-standard pharmacological agent for severe obsessive-compulsive disorder (OCD). Also indicated for treatment-resistant depression, panic disorder, and cataplexy associated with narcolepsy.
Clomipramine Hydrochloride Tablets 25mg
Clomipramine Hydrochloride is a chlorinated tricyclic antidepressant with exceptionally potent and selective serotonin reuptake inhibition compared to other TCAs. Its demethylated metabolite acts as a norepinephrine reuptake inhibitor. Considered the gold-standard pharmacological agent for severe obsessive-compulsive disorder (OCD). Also indicated for treatment-resistant depression, panic disorder, and cataplexy associated with narcolepsy.
Clomipramine Hydrochloride Tablets 50mg
Clomipramine Hydrochloride is a chlorinated tricyclic antidepressant with exceptionally potent and selective serotonin reuptake inhibition compared to other TCAs. Its demethylated metabolite acts as a norepinephrine reuptake inhibitor. Considered the gold-standard pharmacological agent for severe obsessive-compulsive disorder (OCD). Also indicated for treatment-resistant depression, panic disorder, and cataplexy associated with narcolepsy.