TabletsClinical Overview
Sofosbuvir Tablets (400mg) is a nucleotide analogue direct-acting antiviral on the WHO Model List of Essential Medicines. In hepatocytes, it is converted into active triphosphate GS-461203, which acts as a defective substrate for HCV NS5B RNA-dependent RNA polymerase, causing viral chain termination. Indicated in combination with other antiviral agents (daclatasvir, velpatasvir, or ribavirin) for the treatment of chronic hepatitis C across genotypes 1, 2, 3, 4, 5, and 6.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 400 mg once daily with or without food. Swallow whole. Never use as monotherapy; must always be combined with an NS5A inhibitor or ribavirin for 12 to 24 weeks.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Fatigue, headache, nausea, insomnia, anemia (when paired with ribavirin). Rare/Severe: Life-threatening bradycardia with amiodarone, and HBV reactivation.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning for HBV reactivation; screen all patients for HBV surface antigen and core antibody. Life-threatening bradycardia when taken with amiodarone. Safe in renal impairment (no dose adjustment required even in ESRD/dialysis under updated guidelines).
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.