Sucralfate

Sucralfate Suspension (500mg/5ml) is an oral basic aluminum salt of sucrose octasulfate on the WHO Model List of Essential Medicines. Under acidic conditions (pH < 4), it polymerizes into an insoluble, polyanionic gel that adheres tenaciously to ulcerated mucosal tissue, protecting the ulcer crater from gastric acid, pepsin, and bile acids while stimulating endogenous prostaglandin synthesis and epidermal growth factor. Indicated for active duodenal ulcers, gastric ulcers, stress ulcer prophylaxis, and reflux esophagitis.

Sucralfate (1g) and Oxetacaine (10mg) Suspension (per 10ml) combines a cytoprotective mucosal adherent with a potent local anesthetic. In the presence of gastric acid, sucralfate polymerizes into a viscous paste that selectively binds to positively charged proteinaceous exudates on ulcer craters, forming a protective physical barrier against acid, pepsin, and bile salts. Oxetacaine provides surface anesthesia to gastric and esophageal mucosa even in strongly acidic conditions (pH 1-2), delivering rapid relief from intense burning pain. Indicated for active gastric ulcers, duodenal ulcers, severe erosive esophagitis, and acute gastritis with severe epigastric pain.

Lignocaine (4% w/w), Metronidazole (1% w/w), and Sucralfate (7% w/w) Cream is a specialized topical rectal formulation. Lignocaine produces rapid local analgesia by blocking voltage-gated sodium channels. Metronidazole provides topical antimicrobial activity against anaerobic rectal flora, reducing secondary infection and inflammation. Sucralfate forms an adhesive barrier over mucosal fissures and hemorrhoidal ulcers, accelerating re-epithelialization and tissue healing. Indicated for acute and chronic anal fissures, painful thrombosed hemorrhoids, and post-hemorrhoidectomy wound healing.