Sodium Picosulfate

Liquid Paraffin (1.25ml/3.75ml), Milk of Magnesia (3.75ml/11.25ml), and Sodium Picosulphate (3.33mg) Suspension is a triple-action laxative combining a stool lubricant, an osmotic laxative, and a contact stimulant. Liquid paraffin softens and lubricates stools; Milk of Magnesia (magnesium hydroxide) draws water osmotically into the bowel lumen; and sodium picosulphate is activated by colonic sulfatases to stimulate myenteric peristalsis. Indicated for acute and chronic severe constipation, painful anorectal conditions (piles, anal fissures), and post-surgical bowel clearance.

Sodium Picosulphate Tablets (10mg) is an oral prodrug stimulant contact laxative on the WHO Model List framework. It passes unabsorbed through the stomach and small intestine to the colon, where bacterial sulfatases hydrolyze it to the active free diphenol metabolite (BHPM). This metabolite stimulates mucosal sensory nerve endings to induce strong colonic propulsive contractions within 6 to 12 hours. Indicated for short-term management of constipation and colon preparation prior to colonoscopy.