Vitamin B12 (Methylcobalamin)

Methylcobalamin Injection (500mcg/ml, 1500mcg/ml) is a parenteral coenzyme form of vitamin B12 on the WHO Model List framework. Bypasses intestinal intrinsic factor absorption barriers to replenish intracellular cobalamin pools, promoting neuronal myelin sheath synthesis, axonal regeneration, and methionine synthase remethylation of homocysteine. Indicated for severe peripheral neuropathy, diabetic neuropathy, megaloblastic anemia, subacute combined degeneration of the spinal cord, and pernicious anemia.

Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.

Gabapentin is a structural GABA analogue that acts selectively by binding to the alpha-2-delta-1 subunit of presynaptic voltage-dependent calcium channels, attenuating calcium influx in hyper-excited spinal and cerebral neurons. Indicated for post-herpetic neuralgia, painful diabetic peripheral neuropathy, and adjunctive therapy in partial-onset seizures with or without secondary generalization.

Gabapentin is a structural GABA analogue that acts selectively by binding to the alpha-2-delta-1 subunit of presynaptic voltage-dependent calcium channels, attenuating calcium influx in hyper-excited spinal and cerebral neurons. Indicated for post-herpetic neuralgia, painful diabetic peripheral neuropathy, and adjunctive therapy in partial-onset seizures with or without secondary generalization.

Pregabalin and Nortriptyline combines a gabapentinoid voltage-gated calcium channel modulator with a tricyclic antidepressant (TCA). Pregabalin binds the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the CNS, diminishing calcium influx and the exocytosis of excitatory neurotransmitters (glutamate, substance P, noradrenaline). Nortriptyline inhibits presynaptic reuptake of serotonin and noradrenaline, enhancing descending inhibitory pain pathways in the spinal dorsal horn. Indicated for moderate-to-severe neuropathic pain, diabetic peripheral neuropathy, and post-herpetic neuralgia.

Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.

Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.

Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.

Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.