CapsulesMRP Under Process
Official PMBI MRP is being updated for catalog code 2541.
Locate Jan Aushadhi KendraClinical Overview
Duloxetine is a potent, balanced dual serotonin and norepinephrine reuptake inhibitor (SNRI). It inhibits both 5-HT and NE reuptake in the central nervous system, boosting descending inhibitory pain pathways and elevating mood. Gastro-resistant formulation protects the acid-labile drug from gastric degradation. Indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Swallow whole with a full glass of water, with or without meals. Do not chew, crush, or open capsules to sprinkle pellets, as acid exposure inactivates the medication. Do not discontinue abruptly; taper gradually.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dry mouth, somnolence, constipation, insomnia, dizziness, fatigue, diaphoresis. Rare/Severe: Boxed warning: Suicidal ideation; hepatotoxicity/hepatic failure, orthostatic hypotension, serotonin syndrome, and urinary retention.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality in young adults. Contraindicated in patients with hepatic impairment, severe renal impairment (CrCl < 30 mL/min), or uncontrolled narrow-angle glaucoma. Monitor blood pressure and liver enzymes regularly. Avoid heavy alcohol use.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Methylcobalamin Injection 500 mcg
Methylcobalamin Injection (500mcg/ml, 1500mcg/ml) is a parenteral coenzyme form of vitamin B12 on the WHO Model List framework. Bypasses intestinal intrinsic factor absorption barriers to replenish intracellular cobalamin pools, promoting neuronal myelin sheath synthesis, axonal regeneration, and methionine synthase remethylation of homocysteine. Indicated for severe peripheral neuropathy, diabetic neuropathy, megaloblastic anemia, subacute combined degeneration of the spinal cord, and pernicious anemia.
Pregabalin 75mg + Methylcobalamin 750mcg Tablets
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Gabapentin 100mg + Methylcobalamin 500mcg Tablets
Gabapentin is a structural GABA analogue that acts selectively by binding to the alpha-2-delta-1 subunit of presynaptic voltage-dependent calcium channels, attenuating calcium influx in hyper-excited spinal and cerebral neurons. Indicated for post-herpetic neuralgia, painful diabetic peripheral neuropathy, and adjunctive therapy in partial-onset seizures with or without secondary generalization.
Gabapentin 300mg + Methylcobalamin 500mcg Tablet
Gabapentin is a structural GABA analogue that acts selectively by binding to the alpha-2-delta-1 subunit of presynaptic voltage-dependent calcium channels, attenuating calcium influx in hyper-excited spinal and cerebral neurons. Indicated for post-herpetic neuralgia, painful diabetic peripheral neuropathy, and adjunctive therapy in partial-onset seizures with or without secondary generalization.