Flupentixol

Flupentixol is a thioxanthene typical antipsychotic. At low doses (1-3 mg/day), it blocks presynaptic dopamine autoreceptors, stimulating dopamine turnover and exerting disinhibiting, mood-elevating, and anxiolytic effects; at higher doses, it blocks postsynaptic D2 receptors to control hallucinations and delusions. Indicated for maintenance treatment of schizophrenia, paranoid psychoses, and low-dose management of chronic depression with apathy.

Flupentixol and Melitracen is a classic psychoanaleptic fixed-dose combination. Flupentixol, a thioxanthene derivative, acts at low doses (0.5 mg) preferentially on presynaptic dopamine autoreceptors to increase dopaminergic tone and relieve apathy and anxiety, while melitracen, a bipolar tricyclic antidepressant, inhibits norepinephrine and serotonin reuptake. Together, they provide activating, anxiolytic, and mood-lifting action without causing marked sedation. Indicated for psychogenic depression, depressive neuroses, masked depression, and psychosomatic disorders accompanied by anxiety and apathy.

Nortriptyline Hydrochloride is a secondary amine tricyclic antidepressant and the active demethylated metabolite of amitriptyline. It selectively inhibits the reuptake of norepinephrine over serotonin, offering effective antidepressant and neuropathic analgesia with significantly less sedation, anticholinergic burden, and orthostatic hypotension than amitriptyline. Indicated for major depressive disorder and chronic neuropathic pain syndromes.