TabletsClinical Overview
Febuxostat Tablets (40mg, 80mg) is an oral non-purine selective inhibitor of xanthine oxidase on the WHO Model List of Essential Medicines. It achieves potent, durable inhibition by binding directly into the channel leading to the molybdenum pterin active center of both the oxidized and reduced forms of xanthine oxidase, with virtually zero inhibition of other enzymes involved in purine or pyrimidine metabolism. Unlike allopurinol, it is predominantly metabolized by hepatic glucuronidation and oxidation, requiring no dose adjustments in mild-to-moderate renal impairment. Indicated for chronic management of hyperuricemia in adult patients with gout who have had an inadequate response to or intolerance of allopurinol.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 40 mg to 80 mg once daily with water, with or without food. Co-administer prophylactic colchicine (0.5 mg daily) or an NSAID for at least 6 months to prevent mobilization gout flares.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Initial gout flares, liver function abnormalities (elevated AST/ALT), nausea, arthralgia, rash. Rare/Severe: Cardiovascular thrombotic death / stroke, severe hepatotoxicity, and hypersensitivity reactions (DRESS syndrome).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Cardiovascular death risk; reserve febuxostat for patients who cannot tolerate or fail allopurinol, and monitor for signs of myocardial infarction or stroke. Do not start during an acute gout attack. Monitor liver enzymes at baseline and periodically. Strictly contraindicated with azathioprine or mercaptopurine.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.