Clinical Overview
Donepezil Hydrochloride is a reversible, non-competitive, highly selective piperidine acetylcholinesterase (AChE) inhibitor on the WHO Model List of Essential Medicines. It increases synaptic acetylcholine availability in the cerebral cortex and hippocampus by inhibiting its breakdown. Indicated for mild, moderate, and severe dementia of the Alzheimer's type.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily immediately before bedtime with water, with or without food. Taking at bedtime reduces nausea and dizziness. Maintain therapy continuously for clinical benefit.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, anorexia, weight loss. Rare/Severe: Symptomatic bradycardia, sinus node dysfunction, heart block, syncope, peptic ulceration, and neuroleptic malignant syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Vagotonic actions may precipitate severe bradycardia and syncope; monitor pulse in patients with cardiac conduction disorders. Increases gastric acid secretion; monitor for signs of gastrointestinal bleeding. Avoid anticholinergic drugs which antagonize donepezil's actions.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Donepezil Tablets 5 mg
Donepezil Hydrochloride is a reversible, non-competitive, highly selective piperidine acetylcholinesterase (AChE) inhibitor on the WHO Model List of Essential Medicines. It increases synaptic acetylcholine availability in the cerebral cortex and hippocampus by inhibiting its breakdown. Indicated for mild, moderate, and severe dementia of the Alzheimer's type.
Donepezil 5mg + Memantine 5mg Tablets
Donepezil and Memantine is a complementary dual-mechanism formulation for moderate-to-severe dementia. Donepezil, a reversible piperidine acetylcholinesterase inhibitor, increases acetylcholine concentrations at cerebral synapses, while memantine, an uncompetitive NMDA receptor antagonist, protects cholinergic neurons against pathological chronic glutamate-mediated excitotoxicity. Indicated for moderate-to-severe dementia of the Alzheimer's type.
Donepezil 5mg + Memantine 10mg Tablets
Donepezil and Memantine is a complementary dual-mechanism formulation for moderate-to-severe dementia. Donepezil, a reversible piperidine acetylcholinesterase inhibitor, increases acetylcholine concentrations at cerebral synapses, while memantine, an uncompetitive NMDA receptor antagonist, protects cholinergic neurons against pathological chronic glutamate-mediated excitotoxicity. Indicated for moderate-to-severe dementia of the Alzheimer's type.
Donepezil Hydrochloride Orally Disintegrating Strips 10 mg
Donepezil Hydrochloride is a reversible, non-competitive, highly selective piperidine acetylcholinesterase (AChE) inhibitor on the WHO Model List of Essential Medicines. It increases synaptic acetylcholine availability in the cerebral cortex and hippocampus by inhibiting its breakdown. Indicated for mild, moderate, and severe dementia of the Alzheimer's type.