InjectionClinical Overview
Daunorubicin Hydrochloride Injection (20mg) is an anthracycline antineoplastic antibiotic on the WHO Model List of Essential Medicines. It intercalates between DNA base pairs and inhibits topoisomerase II, producing cytotoxic double-strand DNA breaks. Indicated in combination with cytarabine ("7+3" induction regimen) for remission induction in acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer by rapid intravenous infusion into a freely running IV line over 30 to 45 minutes. Exercise extreme caution to prevent extravasation. Cumulative lifetime dose must not exceed 550 mg/m² (or 400 mg/m² if prior chest radiation).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Bone marrow suppression (profound neutropenia, thrombocytopenia), red-colored urine, alopecia, nausea, mucositis. Rare/Severe: Dose-dependent cardiomyopathy, extravasation tissue necrosis, and secondary leukemias.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Severe cardiotoxicity and extravasation necrosis. Vesicant agent. Evaluate cardiac ejection fraction prior to treatment. Contraindicated in pre-existing severe myocardial insufficiency or severe bone marrow depression.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, oncological diagnosis, or chemotherapy protocol guidance. Cancer therapies require specialized administration under the direct supervision of a registered medical oncologist in an accredited healthcare facility.