TabletsClinical Overview
Doxofylline Tablets (400mg; alone or with Montelukast 10mg) is a novel xanthine derivative bronchodilator on the PMBI formulary. Unlike theophylline, it contains a dioxolane group at position 7 that specifically inhibits phosphodiesterase without binding to adenosine receptors or interfering with calcium influx. This confers potent bronchodilatory and anti-inflammatory activity with dramatically fewer cardiac, gastric, and CNS side effects (negligible tachycardia, insomnia, or gastric hypersecretion) and a 10-fold wider therapeutic window. Indicated for maintenance treatment of bronchial asthma, COPD, and spastic bronchitis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 400 mg once or twice daily with a full glass of water, with or after meals. Swallow whole.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild nausea, headache, epigastric discomfort, irritability, insomnia (far less frequent than theophylline). Rare/Severe: Palpitations, arrhythmias, and seizures at massive supratherapeutic doses.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Does not require routine therapeutic drug monitoring unlike theophylline. Use with caution in severe congestive heart failure, hepatic impairment, and active peptic ulcer disease. Safe alternative for patients intolerant to theophylline.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, pulmonological diagnosis, or respiratory management recommendations. Inhalation therapies and allergy medications should be used strictly under the guidance of a qualified pulmonologist or registered medical practitioner.