InjectionClinical Overview
Imipenem and Cilastatin is a broad-spectrum carbapenem antibiotic formulated with an enzyme inhibitor. Imipenem provides potent bactericidal action by inhibiting bacterial cell wall synthesis, while cilastatin inhibits renal dehydropeptidase-I (DHP-I) in the renal brush border, preventing renal metabolism of imipenem, blocking nephrotoxic metabolites, and maintaining high urinary drug concentrations. Indicated for severe polymicrobial infections, hospital-acquired pneumonia, sepsis, intra-abdominal infections, and complicated UTIs.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administered strictly by a qualified healthcare professional by slow intravenous infusion over 20 to 60 minutes. Reconstitute only with compatible diluents. Rapid infusion can provoke nausea and dizziness.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, vomiting, diarrhea, phlebitis, rash, fever. Rare/Severe: Central nervous system toxicity and seizures (especially in patients with CNS lesions or renal impairment receiving high doses), anaphylaxis, and pseudomembranous colitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in carbapenem hypersensitivity. Caution in patients with CNS disease or renal impairment. Dosage reduction is mandatory in renal dysfunction to avoid seizure activity. Concomitant use with valproic acid drastically lowers valproate levels.
Schedule H1 (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.