TabletsClinical Overview
Amlodipine (or S-Amlodipine, the pure chirally active enantiomer with lower incidence of ankle edema) is a third-generation dihydropyridine calcium channel blocker on the WHO Model List of Essential Medicines. It inhibits transmembrane influx of extracellular calcium ions into vascular smooth muscle and cardiac muscle through L-type channels, resulting in potent peripheral arterial and coronary vasodilation with an exceptionally long half-life (30-50 hours). Indicated for essential hypertension, chronic stable angina pectoris, and vasospastic (Prinzmetal's) angina.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily with a glass of water, with or without meals. Maintain consistent daily timing. Can be taken morning or evening.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dose-dependent peripheral ankle edema, flushing, palpitations, dizziness, headache, fatigue, nausea. Rare/Severe: Severe hypotension, paradoxical worsening of angina/myocardial infarction upon initiation or dose increase in severe obstructive CAD, and gingival hyperplasia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Pedal edema is a localized hydrostatic phenomenon, not heart failure; S-enantiomer formulations or co-administration with ARBs/ACEIs reduces its occurrence. Caution in severe aortic stenosis and severe hepatic impairment.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified cardiologist/pharmacist before initiating, altering, or substituting any cardiovascular medication.
Amlodipine 5mg + Atenolol 50mg Tablets
Amlodipine and Atenolol is a classic dual-mechanism cardiovascular combination pairing a dihydropyridine calcium channel blocker with a cardioselective beta-1 blocker. Amlodipine lowers peripheral vascular resistance and dilates coronary arteries, while atenolol reduces resting and exercise heart rates, suppresses cardiac contractility, and eliminates the reflex tachycardia typically triggered by dihydropyridine vasodilation. Indicated for essential hypertension and stable chronic angina pectoris.
Amlodipine Tablets 5mg
Amlodipine (or S-Amlodipine, the pure chirally active enantiomer with lower incidence of ankle edema) is a third-generation dihydropyridine calcium channel blocker on the WHO Model List of Essential Medicines. It inhibits transmembrane influx of extracellular calcium ions into vascular smooth muscle and cardiac muscle through L-type channels, resulting in potent peripheral arterial and coronary vasodilation with an exceptionally long half-life (30-50 hours). Indicated for essential hypertension, chronic stable angina pectoris, and vasospastic (Prinzmetal's) angina.
Lisinopril Tablets 5mg
Angiotensin Converting Enzyme (ACE) Inhibitor on the WHO Model List of Essential Medicines. It blocks the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, reducing peripheral arterial resistance, decreasing aldosterone secretion, and inhibiting the enzymatic degradation of bradykinin, producing potent vasodilation and cardioprotection. Indicated for essential hypertension, heart failure with reduced ejection fraction (HFrEF), post-myocardial infarction, and diabetic nephropathy.
Telmisartan 40mg + Amlodipine 5mg Tablets
Telmisartan and Amlodipine is a synergistic dual antihypertensive formulation. Telmisartan blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II at AT1 receptors and improves insulin sensitivity via partial PPAR-gamma agonism, while amlodipine selectively inhibits transmembrane calcium influx in vascular smooth muscle, producing peripheral arteriolar vasodilation. Telmisartan post-capillary venodilation mitigates amlodipine-induced pre-capillary peripheral ankle edema. Indicated for essential hypertension in patients whose blood pressure is not adequately controlled on monotherapy.