TabletsClinical Overview
Perampanel is a first-in-class, highly selective, non-competitive antagonist at postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors on excitatory neurons. By targeting the primary mediator of fast excitatory synaptic transmission in the brain, it halts seizure propagation. Indicated as adjunctive therapy for partial-onset seizures and primary generalized tonic-clonic seizures.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily immediately before bedtime with water, with or without food. Bedtime dosing minimizes daytime dizziness and somnolence. Titrate slowly at minimum 1-to-2 week intervals.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dizziness, somnolence, fatigue, irritability, ataxia, vertigo, weight gain, nausea. Rare/Severe: Boxed warning: Serious psychiatric and behavioral reactions (severe aggression, hostility, anger, homicidal thoughts and threats), falls, and severe hypersensitivity.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Serious neuropsychiatric events including hostility, severe aggression, and homicidal ideation; monitor patients and instruct families to report sudden personality or behavioral changes immediately. Dose-dependent risk of dizziness and severe falls.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.