PowderMRP Under Process
Official PMBI MRP is being updated for catalog code 2742.
Locate Jan Aushadhi KendraClinical Overview
Romiplostim is a recombinant thrombopoietin (TPO) receptor agonist "peptibody." It binds to and activates the human TPO receptor (c-Mpl) on megakaryocytes and hematopoietic stem cells via the JAK/STAT pathway, stimulating megakaryocyte proliferation and platelet production. Indicated for immune thrombocytopenia (ITP) in adults refractory to corticosteroids, immunoglobulins, or splenectomy.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administered solely by a registered healthcare professional via weekly subcutaneous injection after reconstitution. Weekly dosage is titrated based on platelet counts (target: 50,000 to 200,000/mcL).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Headache, arthralgia, dizziness, insomnia, myalgia, pain in extremity, abdominal pain. Rare/Severe: Thrombotic/thromboembolic complications, bone marrow reticulin fiber formation (reticulin fibrosis), loss of response due to neutralizing antibodies, and progression of myelodysplastic syndromes to acute myeloid leukemia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Excessive platelet counts increase thromboembolic risk; weekly complete blood counts are mandatory until a stable platelet count is achieved. Not indicated for treatment of thrombocytopenia due to myelodysplastic syndrome (MDS) due to risk of progression to AML.
Schedule H (Prescription Required - Specialist Hematology Use)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified cardiologist/pharmacist before initiating, altering, or substituting any cardiovascular medication.