TabletsClinical Overview
Torasemide (10mg) and Spironolactone (25mg) Tablets is a fixed-dose loop and potassium-sparing diuretic combination on the WHO Model List framework. Torasemide inhibits the Na+/K+/2Cl- symporter in the thick ascending limb of Henle's loop, producing potent natriuresis and diuresis. Spironolactone competitively antagonizes the mineralocorticoid aldosterone receptor in the distal convoluted tubule and collecting duct, promoting sodium and water excretion while conserving potassium and magnesium ions. Indicated for refractory edema and ascites associated with congestive heart failure, hepatic cirrhosis, and nephrotic syndrome.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily in the morning with breakfast with a glass of water to avoid nocturia. Follow physician advice regarding dietary sodium and potassium intake.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild dizziness, headache, frequent urination, gynecomastia (breast tenderness/enlargement in males from spironolactone), menstrual irregularities. Rare/Severe: Hyperkalemia, profound dehydration, hyponatremia, and renal impairment.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Regularly monitor serum potassium, sodium, and creatinine; strictly contraindicated in hyperkalemia (serum K+ > 5.5 mEq/L) and acute anuric renal failure. Avoid potassium supplements and salt substitutes containing potassium. Caution with ACE inhibitors or ARBs.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, nephrological diagnosis, or urological treatment recommendations. Always consult a registered nephrologist, urologist, or qualified medical practitioner before initiating, modifying, or discontinuing any kidney or urinary tract medication.
Torasemide Tablets 10mg
Torasemide is a high-ceiling loop diuretic of the pyridine-sulfonylurea class. It inhibits the Na+/K+/2Cl- luminal carrier in the thick ascending limb of Henle's loop, producing potent natriuresis and diuresis. Unlike furosemide, torasemide features high, predictable oral bioavailability (around 80%), a longer duration of action, and antialdosterone properties that decrease myocardial collagen accumulation. Indicated for edema associated with congestive heart failure, chronic renal failure, and hepatic cirrhosis, and for essential hypertension.
Spironolactone Tablets 25 mg
Spironolactone is a synthetic steroid competitive mineralocorticoid receptor (aldosterone) antagonist and potassium-sparing diuretic on the WHO Model List of Essential Medicines. It blocks aldosterone binding in the late distal renal tubules and cortical collecting ducts, increasing sodium and water excretion while conserving potassium and hydrogen ions. In heart failure, it blocks aldosterone-mediated myocardial fibrosis and endothelial dysfunction. Indicated for heart failure with reduced ejection fraction (NYHA class II-IV), primary hyperaldosteronism, cirrhosis with ascites, resistant hypertension, and nephrotic edema.
Frusemide 20mg + Spironolactone 50mg Tablets
Spironolactone is a synthetic steroid competitive mineralocorticoid receptor (aldosterone) antagonist and potassium-sparing diuretic on the WHO Model List of Essential Medicines. It blocks aldosterone binding in the late distal renal tubules and cortical collecting ducts, increasing sodium and water excretion while conserving potassium and hydrogen ions. In heart failure, it blocks aldosterone-mediated myocardial fibrosis and endothelial dysfunction. Indicated for heart failure with reduced ejection fraction (NYHA class II-IV), primary hyperaldosteronism, cirrhosis with ascites, resistant hypertension, and nephrotic edema.
Torsemide 10mg + Spironolactone 50mg Tablets
Spironolactone is a synthetic steroid competitive mineralocorticoid receptor (aldosterone) antagonist and potassium-sparing diuretic on the WHO Model List of Essential Medicines. It blocks aldosterone binding in the late distal renal tubules and cortical collecting ducts, increasing sodium and water excretion while conserving potassium and hydrogen ions. In heart failure, it blocks aldosterone-mediated myocardial fibrosis and endothelial dysfunction. Indicated for heart failure with reduced ejection fraction (NYHA class II-IV), primary hyperaldosteronism, cirrhosis with ascites, resistant hypertension, and nephrotic edema.