TabletsClinical Overview
Midodrine Hydrochloride is an oral prodrug that is enzymatically hydrolyzed by systemic deglycination to desglymidodrine, a potent, selective, peripherally-acting alpha-1 adrenergic receptor agonist. It acts directly on alpha-1 receptors of arteriolar and venous vasculature to increase vascular tone and total peripheral resistance, elevating systolic and diastolic blood pressure and reducing venous pooling. Indicated for the treatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with a glass of water during daytime hours when the patient is upright and pursuing daily activities (e.g. at 3- to 4-hour intervals: morning, midday, and late afternoon). Do NOT take within 4 hours of bedtime to prevent severe supine hypertension during sleep.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Piloerection ("goosebumps"), scalp pruritus, tingling sensation, urinary retention, dysuria, chills. Rare/Severe: Boxed warning: Marked supine hypertension (systolic blood pressure elevation > 200 mmHg when lying down); reflex bradycardia, and urinary tract obstruction.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Can cause marked elevation in supine blood pressure; strictly avoid taking before lying down for sleep, and measure supine and sitting blood pressure regularly. Sleep with head elevated. Contraindicated in severe organic heart disease, acute renal failure, urinary retention, and thyrotoxicosis.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified cardiologist/pharmacist before initiating, altering, or substituting any cardiovascular medication.
Midodrine Hydrochloride Tablets 2.5mg
Midodrine Hydrochloride is an oral prodrug that is enzymatically hydrolyzed by systemic deglycination to desglymidodrine, a potent, selective, peripherally-acting alpha-1 adrenergic receptor agonist. It acts directly on alpha-1 receptors of arteriolar and venous vasculature to increase vascular tone and total peripheral resistance, elevating systolic and diastolic blood pressure and reducing venous pooling. Indicated for the treatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care.
Midodrine Hydrochloride Tablets 5mg
Midodrine Hydrochloride is an oral prodrug that is enzymatically hydrolyzed by systemic deglycination to desglymidodrine, a potent, selective, peripherally-acting alpha-1 adrenergic receptor agonist. It acts directly on alpha-1 receptors of arteriolar and venous vasculature to increase vascular tone and total peripheral resistance, elevating systolic and diastolic blood pressure and reducing venous pooling. Indicated for the treatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care.