TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2367.
Locate Jan Aushadhi KendraClinical Overview
Methimazole / Carbimazole (prodrug of methimazole) is a thionamide antithyroid drug on the WHO Model List of Essential Medicines. It inhibits the enzyme thyroid peroxidase (TPO), preventing the oxidation of iodide to iodine and blocking the organification and coupling of iodotyrosine residues on thyroglobulin, halting the synthesis of thyroid hormones T3 and T4. Indicated for the medical management of hyperthyroidism in Graves' disease, toxic multinodular goiter, preparation for radioactive iodine or thyroidectomy, and thyrotoxic crisis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with a glass of water, once daily or divided two to three times daily, with or after meals to minimize stomach upset. Complete regular blood counts and thyroid function tests (FT3, FT4, TSH) as scheduled.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild skin rash, pruritus, urticaria, arthralgia, nausea, headache, mild leukopenia. Rare/Severe: Boxed warning: Life-threatening agranulocytosis (profound absolute neutrophil count < 500/mcL); severe hepatotoxicity, vasculitis (ANCA-positive), and aplasia cutis in neonates (if used in first trimester).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Major safety warning: Can cause sudden, life-threatening agranulocytosis; patients MUST be instructed to report immediate sore throat, mouth ulcers, or fever, and obtain an urgent complete blood count (CBC). Preferred over propylthiouracil due to lower hepatotoxicity, except in the first trimester of pregnancy where PTU is preferred due to methimazole embryopathy risk.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered endocrinologist, diabetologist, or qualified physician before initiating, adjusting dosages of, or substituting any antidiabetic or hormonal medication.