CapsulesClinical Overview
Ziprasidone is an atypical antipsychotic featuring a high 5-HT2A/D2 receptor binding ratio, potent 5-HT1A agonism, 5-HT1D and 5-HT2C antagonism, and moderate inhibition of synaptic serotonin and norepinephrine reuptake. Demonstrates very low propensity for weight gain, diabetes, and hyperlipidemia. Indicated for schizophrenia and acute manic or mixed episodes in bipolar I disorder.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Swallow capsules whole strictly with a meal of at least 500 calories, which doubles bioavailability. Take twice daily as prescribed. Taper before discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, dizziness, nausea, headache, dry mouth, akathisia. Rare/Severe: Boxed warning: Mortality in dementia patients; dose-dependent QT prolongation, torsades de pointes, DRESS syndrome, and neuroleptic malignant syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for dementia psychosis mortality. Contraindicated in patients with history of QT prolongation, recent acute myocardial infarction, uncompensated heart failure, or concurrent QT-prolonging antiarrhythmics. Must take with food (>=500 kcal).
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.