CapsulesClinical Overview
Tretinoin (all-trans retinoic acid) is a topical retinoid on the WHO Model List of Essential Medicines. It binds to nuclear retinoic acid receptors (RAR), modifying gene expression to decrease follicular epithelial cohesiveness, stimulating mitotic turnover of follicular epithelial cells, expelling existing comedones, and preventing new microcomedone formation. Indicated for topical treatment of acne vulgaris and photoaged skin (fine facial wrinkles).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Wash face with a gentle cleanser, wait 20-30 minutes for skin to dry completely, then apply a pea-sized amount once daily at bedtime. Avoid eyes, mouth, and mucous membranes. Use daily daytime moisturizer and broad-spectrum sunscreen.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: "Retinoid dermatitis" (erythema, scaling, peeling, dryness, stinging), initial acne flare/purging in weeks 2-4, photosensitivity. Rare/Severe: Severe chemical dermatitis, blistering, and hyper/hypopigmentation.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Strictly contraindicated during pregnancy. Marked photosensitization; daily broad-spectrum sunscreen is mandatory. Do not apply around eyes or open skin.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Adapalene Gel 0.1%
Adapalene (0.1% w/w gel) is a third-generation synthetic retinoid on the WHO Model List of Essential Medicines. It selectively modulates cellular differentiation and keratinization by binding to retinoic acid receptors beta and gamma, inhibiting microcomedone formation and down-regulating inflammatory lipoxygenase pathways. Exhibits greater chemical stability and lower cutaneous irritation than tretinoin. Indicated for the topical treatment of acne vulgaris.
Hydroquinone 2%, Mometasone 0.1% and Tretinoin 0.025% Cream
Hydroquinone, Tretinoin, and Fluocinolone Acetonide is the gold-standard Triple Combination Cream (Kligman's formula) for refractory melasma. Hydroquinone (2-4%) competitively inhibits tyrosinase, blocking melanin pigment synthesis; Tretinoin (0.05%) accelerates epidermal turnover and keratinocyte shedding, facilitating hydroquinone penetration and dispersing melanin; and Fluocinolone Acetonide (0.01%), a mild-to-moderate topical corticosteroid, suppresses melanocyte inflammation and counteracts the irritant dermatitis of hydroquinone and tretinoin. Indicated for the short-term moderate-to-severe melasma of the face.
Betamethasone Dipropionate 0.05% and Salicylic Acid 3% Ointment
Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.
Clobetasol Propionate 0.05% and Salicylic Acid 3% Ointment
Clobetasol Propionate (0.05%) and Salicylic Acid (3% or 6%) ointment is a potent keratolytic-corticosteroid combination for hyperkeratotic dermatoses. Clobetasol is an ultra-high potency (Class I) topical corticosteroid that produces rapid vasoconstriction, anti-inflammatory, and immunosuppressive actions, while salicylic acid dissolves the intercellular cement of the stratum corneum, desquamating thick adherent scales and enhancing the penetration of clobetasol into the dermis. Indicated for chronic plaque psoriasis, palmoplantar psoriasis, lichen planus, hypertrophic lichen simplex chronicus, and severe hyperkeratotic eczema.