OintmentClinical Overview
Clobetasol Propionate (0.05%) and Salicylic Acid (3% or 6%) ointment is a potent keratolytic-corticosteroid combination for hyperkeratotic dermatoses. Clobetasol is an ultra-high potency (Class I) topical corticosteroid that produces rapid vasoconstriction, anti-inflammatory, and immunosuppressive actions, while salicylic acid dissolves the intercellular cement of the stratum corneum, desquamating thick adherent scales and enhancing the penetration of clobetasol into the dermis. Indicated for chronic plaque psoriasis, palmoplantar psoriasis, lichen planus, hypertrophic lichen simplex chronicus, and severe hyperkeratotic eczema.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Apply a thin film to the thick, scaly plaques once or twice daily. Gently rub in. Do NOT apply under occlusive dressings unless specifically directed. Strictly limit continuous use to a maximum of 2 to 4 weeks and do not exceed 50 g/week to prevent systemic HPA axis suppression.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Local burning, stinging, skin thinning, dryness, pruritus. Rare/Severe: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, cutaneous atrophy (striae, telangiectasia), salicylism (salicylate toxicity with extensive application), and secondary infection.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box caution: Ultra-high potency steroid; strictly avoid application on the face, groin, axillae, or open wounds. Never use in children under 12 years without specialist supervision. Limit duration to 2-4 weeks; taper to a lower potency steroid once plaques flatten.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
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