Clinical Overview
Cyproheptadine Hydrochloride Tablets (4mg) and Syrup (2mg/5ml; alone or with Tricholine Citrate) is a first-generation piperidine antihistamine and potent serotonin 5-HT2 receptor antagonist on the WHO Model List framework. By blocking 5-HT2 serotonergic receptors in the ventromedial satiety center of the hypothalamus, it stimulates appetite and increases caloric intake and body weight. Concurrently, it blocks peripheral H1 histamine receptors and muscarinic receptors. Indicated for appetite stimulation in underweight or failure-to-thrive patients, allergic rhinitis, and urticaria.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Adults: Take 4 mg orally two to three times daily before meals with water. Children (2-6 years): 2 mg two to three times daily. Syrup: Measure accurately with measuring cup. Administer consistently before meals.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Significant sedation, drowsiness, dry mouth, increased appetite and weight gain, fatigue, dizziness. Rare/Severe: Paradoxical CNS excitation in young children, urinary retention, blood dyscrasias, and hypotension.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Causes marked drowsiness; avoid driving or operating dangerous machinery. Contraindicated in infants <2 years, narrow-angle glaucoma, prostatic hypertrophy, bladder neck obstruction, and nursing mothers. Strictly avoid alcohol.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.