TabletsClinical Overview
Dosulepin (Dothiepin) Hydrochloride is a thio-derivative tricyclic antidepressant. It blocks the reuptake of norepinephrine and serotonin while exerting significant central sedative and anxiolytic actions via H1 and 5-HT2 antagonism. Indicated for major depressive illness, particularly when associated with prominent anxiety, agitation, and sleep disturbance.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, preferably as a single dose at bedtime due to its strong sedative properties. Titrate gradually. Taper slowly when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, dry mouth, blurred vision, constipation, sweating, dizziness, weight gain. Rare/Severe: Extreme cardiotoxicity in overdose (fatal ventricular arrhythmias, heart block), seizures, and bone marrow suppression.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
High fatal toxicity index in overdose; strictly restricted in patients with significant suicide risk. Contraindicated in recent myocardial infarction, heart failure, and epilepsy. Avoid alcohol.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Dosulepine (or Dothiepin) Tablets 75mg
Dosulepin (Dothiepin) Hydrochloride is a thio-derivative tricyclic antidepressant. It blocks the reuptake of norepinephrine and serotonin while exerting significant central sedative and anxiolytic actions via H1 and 5-HT2 antagonism. Indicated for major depressive illness, particularly when associated with prominent anxiety, agitation, and sleep disturbance.
Dosulepin (Dothiepin) Tablets 50mg
Dosulepin (Dothiepin) Hydrochloride is a thio-derivative tricyclic antidepressant. It blocks the reuptake of norepinephrine and serotonin while exerting significant central sedative and anxiolytic actions via H1 and 5-HT2 antagonism. Indicated for major depressive illness, particularly when associated with prominent anxiety, agitation, and sleep disturbance.