InjectionClinical Overview
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administered strictly in hospital intensive care units by slow intravenous infusion over 30 to 60 minutes or via specialized nebulization for cystic fibrosis/ventilator-associated tracheobronchitis. Requires precise loading and maintenance dosing calculated by clinical pharmacologists based on ideal body weight and renal function.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild dizziness, local infusion discomfort, nausea. Rare/Severe: Severe nephrotoxicity (acute tubular necrosis, acute renal failure in up to 30-50% of intensive care patients), neurotoxicity (paresthesia, visual disturbances, confusion, neuromuscular blockade causing respiratory arrest).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Nephrotoxicity and neurotoxicity. Daily monitoring of serum creatinine, BUN, and urine output is mandatory. Avoid concomitant administration with other nephrotoxic or neuromuscular-blocking agents. Dose adjustment in renal impairment is critical to prevent fatal toxicity.
Schedule H1 (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Colistimethate Sodium for Injection 4.5 Million IU
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).
Colistin Sulphate Oral Suspension 12.5 mg per 5ml
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).