Colistimethate
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Antibiotics & Anti-Infectives treatment.
🧴 Clinical Application
Administered strictly in hospital intensive care units by slow intravenous infusion over 30 to 60 minutes or via specialized nebulization for cystic fibrosis/ventilator-associated tracheobronchitis. Requires precise loading and maintenance dosing calculated by clinical pharmacologists based on ideal body weight and renal function.
⚠️ Side Effects
Common: Mild dizziness, local infusion discomfort, nausea. Rare/Severe: Severe nephrotoxicity (acute tubular necrosis, acute renal failure in up to 30-50% of intensive care patients), neurotoxicity (paresthesia, visual disturbances, confusion, neuromuscular blockade causing respiratory arrest).
🛡️ Safety Warnings
Black box warning: Nephrotoxicity and neurotoxicity. Daily monitoring of serum creatinine, BUN, and urine output is mandatory. Avoid concomitant administration with other nephrotoxic or neuromuscular-blocking agents. Dose adjustment in renal impairment is critical to prevent fatal toxicity.
Jan Aushadhi Products containing Colistimethate
Found 3 generic formulation(s) containing this active ingredient.
Colistimethate Sodium for Injection 1 Million IU
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).
Colistimethate Sodium for Injection 4.5 Million IU
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).
Colistin Sulphate Oral Suspension 12.5 mg per 5ml
Colistimethate Sodium (Colistin) is a polymyxin bactericidal antibiotic (Polymyxin E). It functions as a cationic detergent that binds to lipopolysaccharides and phospholipids in the outer cell membrane of Gram-negative bacteria, disrupting membrane integrity and causing leakage of intracellular contents. Serves as a critical reserve antibiotic for severe, life-threatening infections caused by carbapenem-resistant Gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae).
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Colistimethate.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Colistimethate Sodium for Injection 1 Million IU | Vial (10 ml) | ₹168.75 | N/A | N/A | N/A |
| Colistimethate Sodium for Injection 4.5 Million IU | Vial (10 ml) | ₹421.88 | N/A | N/A | N/A |
| Colistin Sulphate Oral Suspension 12.5 mg per 5ml | 30 ml | ₹27.19 | N/A | N/A | N/A |
Frequently Asked Questions (FAQ)
Get answers to common queries about Colistimethate generics.