CapsulesClinical Overview
Amantadine Hydrochloride is a synthetic tricyclic amine that acts as a low-affinity, uncompetitive antagonist at NMDA glutamate receptors, while stimulating presynaptic dopamine release and inhibiting dopamine reuptake in the striatum. Indicated for the treatment of levodopa-induced dyskinesias in Parkinson's disease, idiopathic Parkinson's symptoms, and drug-induced extrapyramidal reactions.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, with or after meals. Take the final dose of the day in the afternoon to prevent insomnia. Taper gradually when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dizziness, insomnia, livedo reticularis (purplish net-like skin discoloration on legs), peripheral edema, orthostatic hypotension. Rare/Severe: Hallucinations, delirium, congestive heart failure, corneal edema, and neuroleptic malignant syndrome-like reaction upon abrupt cessation.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Do not discontinue abruptly, as sudden withdrawal can precipitate acute parkinsonian crisis or neuroleptic malignant syndrome. Caution in heart failure, renal impairment, and psychiatric illness. Livedo reticularis is benign and reversible upon drug cessation.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.