TabletsClinical Overview
Modafinil is an atypical wakefulness-promoting agent. Unlike classical amphetamines, it acts as a selective, low-affinity dopamine transporter (DAT) inhibitor while stimulating hypocretin/orexin, histamine, and alpha-1 adrenergic systems in the hypothalamus and tuberomammillary nucleus, promoting alertness without peripheral sympathomimetic overstimulation or rebound hypersomnolence. Indicated for excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily as a single dose in the morning with a glass of water, with or without food. For shift work sleep disorder, take approximately 1 hour before the start of the work shift. Avoid late afternoon dosing to prevent insomnia.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Headache (most frequent), nausea, anxiety, dizziness, insomnia, dry mouth, dyspepsia. Rare/Severe: Severe, life-threatening dermatologic reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), multi-organ hypersensitivity, and psychiatric symptoms (hallucinations, mania).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Discontinue immediately at the first appearance of a skin rash or mouth sores; severe SJS has been reported. Decreases the effectiveness of hormonal contraceptives; alternative or barrier contraceptive methods must be used during and for 2 months after therapy.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.