Tenofovir Disoproxil
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Antibiotics & Anti-Infectives treatment.
🧴 Clinical Application
Take orally once daily or twice daily at the exact same hour every single day. Strict lifelong adherence is paramount to prevent viral rebound and resistance mutation. Do not skip doses or alter timing without specialist guidance.
⚠️ Side Effects
Common: Headache, nausea, fatigue, insomnia, diarrhea, abnormal dreams (with efavirenz). Rare/Severe: Renal tubular dysfunction/Fanconi syndrome (tenofovir disoproxil), loss of bone mineral density, severe hypersensitivity (abacavir HLA-B*5701), lactic acidosis/severe hepatomegaly with steatosis, and immune reconstitution inflammatory syndrome (IRIS).
🛡️ Safety Warnings
Black box warnings: Exacerbation of Hepatitis B upon treatment discontinuation in co-infected patients. HLA-B*5701 genetic testing is mandatory prior to abacavir administration to prevent fatal hypersensitivity. Routine monitoring of renal function, bone density, viral load, and CD4 counts is essential.
Jan Aushadhi Products containing Tenofovir Disoproxil
Found 2 generic formulation(s) containing this active ingredient.
Tenofovir Disoproxil Fumarate Tablets 300 mg
Antiretroviral therapy (ART) formulation comprising nucleotide/nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs), or boosted protease inhibitors (PIs). Engineered to suppress HIV-1 viral replication to undetectable levels, halt disease progression, and restore CD4 immune function.
Tenofovir Alafenamide Tablets 25mg
Tenofovir Alafenamide (TAF) Tablets (25mg) is a targeted prodrug of the nucleotide reverse transcriptase inhibitor tenofovir on the WHO Model List of Essential Medicines. TAF enters hepatocytes through passive diffusion and hepatic OATP1B1/1B3 transporters and is intracellularly hydrolyzed by carboxylesterase 1 (CES1) to tenofovir. This delivers high intracellular antiviral concentrations with over 90% lower systemic plasma tenofovir exposure compared to tenofovir disoproxil fumarate (TDF), dramatically reducing renal tubulopathy and bone mineral density loss. Indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults and adolescents with compensated liver disease.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Tenofovir Disoproxil.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Tenofovir Disoproxil Fumarate Tablets 300 mg | 10's | ₹202.13 | N/A | N/A | N/A |
| Tenofovir Alafenamide Tablets 25mg | 30's in Bottle | ₹562.50 | N/A | N/A | N/A |
Frequently Asked Questions (FAQ)
Get answers to common queries about Tenofovir Disoproxil generics.