Mannitol
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Vitamins, Minerals & Nutrition treatment.
🧴 Clinical Application
Administer intravenously only through an in-line filter (0.22 or 5 micron) over 20 to 60 minutes: 0.25 to 1.0 g/kg body weight (typically 50-100 g as a 20% solution). Inspect solution for crystallization prior to use; if crystals are present, warm container in hot water bath and shake until redissolved, then cool to body temperature before infusing. Insertion of an indwelling Foley catheter is mandatory to monitor massive urinary diuresis.
⚠️ Side Effects
Common: Polyuria, headache, nausea, thirst, dizziness, hypotension. Rare/Severe: Acute pulmonary edema and congestive heart failure (from rapid initial intravascular volume expansion), hyperosmolar state, acute renal failure, and severe electrolyte disturbances (hyponatremia, hypernatremia, hypokalemia).
🛡️ Safety Warnings
Black Box ICU Warning: Contraindicated in severe pulmonary edema, severe congestive heart failure, active intracranial bleeding (except during craniotomy), and established anuric acute renal disease. Transiently expands intravascular volume by 15-20%; closely monitor cardiopulmonary status and serum osmolality (keep serum osmolality < 320 mOsm/kg).
Jan Aushadhi Products containing Mannitol
Found 2 generic formulation(s) containing this active ingredient.
Mannitol Injection 20% w/v
Mannitol Injection / Infusion (20% w/v, 100ml, 350ml) is an intravenous non-metabolizable hexitol osmotic diuretic on the WHO Model List of Essential Medicines. It increases blood osmolality, establishing an osmotic gradient that draws water from intracellular and interstitial spaces of parenchymal tissues (particularly the brain and eye) into the intravascular compartment. In renal tubules, it remains unabsorbed, exerting an osmotic force that prevents water reabsorption in the proximal tubule and loop of Henle, promoting marked water diuresis. Indicated for reduction of dangerously elevated intracranial pressure (ICP) and cerebral edema in traumatic brain injury, acute stroke, and neurosurgery, and rapid reduction of intraocular pressure (IOP) in acute angle-closure glaucoma.
Mannitol Intravenous Infusion 20% w/v
Mannitol Injection / Infusion (20% w/v, 100ml, 350ml) is an intravenous non-metabolizable hexitol osmotic diuretic on the WHO Model List of Essential Medicines. It increases blood osmolality, establishing an osmotic gradient that draws water from intracellular and interstitial spaces of parenchymal tissues (particularly the brain and eye) into the intravascular compartment. In renal tubules, it remains unabsorbed, exerting an osmotic force that prevents water reabsorption in the proximal tubule and loop of Henle, promoting marked water diuresis. Indicated for reduction of dangerously elevated intracranial pressure (ICP) and cerebral edema in traumatic brain injury, acute stroke, and neurosurgery, and rapid reduction of intraocular pressure (IOP) in acute angle-closure glaucoma.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Mannitol.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Mannitol Injection 20% w/v | 100 ml | ₹26.25 | Mannitol, Manitol, Fabitol | ₹29.91 | 12% Save |
| Mannitol Intravenous Infusion 20% w/v | 350 ml | ₹46.88 | Mannitol, Manitol, Fabitol | ₹104.69 | 55% Save |
Frequently Asked Questions (FAQ)
Get answers to common queries about Mannitol generics.