Magnesiumsulphate

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Vitamins, Minerals & Nutrition treatment.

🧴 Clinical Application

Administer intravenously or deep intramuscularly according to validated Pritchard or Zuspan eclampsia regimens under hospital monitoring: IV loading dose of 4 g diluted over 15 to 20 minutes, followed by maintenance infusion of 1 to 2 g/hour. MANDATORY MONITORING: Before administering maintenance doses, verify that patellar deep tendon reflexes are present, respiratory rate is >= 16 breaths/min, and hourly urine output is >= 30 mL/hr. Calcium gluconate 10% IV MUST be immediately available as the antidote for toxicity.

⚠️ Side Effects

Common: Flushing, sensation of warmth, diaphoresis, hypotension, mild drowsiness. Rare/Severe: Loss of deep tendon reflexes (first sign of toxicity), respiratory depression, pulmonary edema, and cardiac arrest.

🛡️ Safety Warnings

Black Box Obstetric Warning: Magnesium toxicity; loss of patellar reflexes occurs at 8-10 mEq/L, respiratory paralysis at 12 mEq/L, and cardiac arrest at >15 mEq/L. Calcium gluconate 10% IV (10 mL) MUST be kept at the bedside as the immediate antidote. Contraindicated in myasthenia gravis and severe heart block.