⚕ Rx (Prescription Required)Oncology & Critical CareAntidotes & Supportive Oncology

Leucovorin

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.

🧴 Clinical Application

Methotrexate rescue: Administer orally (or IV for doses >25 mg) starting exactly 24 hours after the initiation of high-dose methotrexate infusion, typically 15 mg every 6 hours for 8 to 10 doses, until serum methotrexate falls below 0.05-0.1 micromolar. Take with water.

⚠️ Side Effects

Extremely well tolerated. Common: Mild nausea, vomiting, allergic rash, insomnia. Negligible systemic toxicity.

🛡️ Safety Warnings

Do NOT administer intrathecally (lethal). High-dose methotrexate rescue requires precise timing; starting leucovorin too early blunts methotrexate antitumor efficacy, while delaying past 40 hours can result in irreversible, fatal bone marrow and renal aplasia. Does not treat pernicious anemia (can mask neurological damage).

Jan Aushadhi Products containing Leucovorin

Found 1 generic formulation(s) containing this active ingredient.

⚕ Rx OnlyAntidotes & Supportive Oncology

Leucovorin Calcium Tablets 15mg

Tablets
10's

Leucovorin Calcium / Folinic Acid Tablets (15mg) is the 5-formyl derivative of tetrahydrofolic acid (FH4) on the WHO Model List of Essential Medicines. It bypasses the enzymatic block created by dihydrofolate reductase (DHFR) inhibitors (such as methotrexate), directly entering folate cofactor pools to rescue normal host tissues from lethal toxicity ("Leucovorin Rescue"). Concurrently, in 5-fluorouracil chemotherapy, leucovorin stabilizes the ternary binding complex with thymidylate synthase, markedly enhancing 5-FU cytotoxicity. Indicated for rescue therapy following high-dose methotrexate chemotherapy, accidental methotrexate overdose, and potentiation of 5-FU in metastatic colorectal carcinoma.

Price on request
Leucovorin

Brand Equivalents & Price Comparison

Compare Jan Aushadhi generic prices against popular commercial brands for Leucovorin.

Generic FormulationPack SizeJan Aushadhi PriceCommercial Brand EquivalentsAvg. Commercial PriceSavings
Leucovorin Calcium Tablets 15mg10'sUnder ProcessN/AN/AN/A

Frequently Asked Questions (FAQ)

Get answers to common queries about Leucovorin generics.

How many Jan Aushadhi products contain Leucovorin?＋
This directory currently lists 1 Jan Aushadhi generic product(s) containing Leucovorin as an active pharmaceutical ingredient (API). The count reflects the July 2026 PMBI catalog snapshot.
Does Leucovorin require a prescription at Jan Aushadhi Kendras?＋
Yes. Leucovorin is classified as a prescription-required (Rx) ingredient under applicable Indian drug schedules. You must present a valid prescription from a registered medical practitioner to obtain it at a Jan Aushadhi Kendra.
What is the lowest listed price for Leucovorin at Jan Aushadhi?＋
Price data for Leucovorin formulations is currently listed as "under process" in the July 2026 PMBI catalog. Visit a Jan Aushadhi Kendra and quote the product drug code for the applicable MRP.
Are Jan Aushadhi Leucovorin products clinically equivalent to branded versions?＋
Jan Aushadhi generics contain the same declared active pharmaceutical ingredient (Leucovorin) at the same concentration as branded counterparts and must meet CDSCO quality standards. However, inactive excipients, release mechanisms, and manufacturing processes can differ between manufacturers. Never switch a prescribed medicine without consulting your doctor.
Find a Jan Aushadhi Kendra Near You
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