Cisplatin
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.
🧴 Clinical Application
Administer intravenously only as an IV infusion (usually 20 to 100 mg/m² per cycle) over 1 to 2 hours. Mandatory pre-hydration and post-hydration with at least 1 to 2 liters of normal saline containing mannitol is required to induce vigorous diuresis and prevent severe nephrotoxicity. Premedicate with 5-HT3 antagonists and dexamethasone for high emetogenic potential.
⚠️ Side Effects
Common: Severe acute and delayed nausea and vomiting (emetogenic level 5, >90%), cumulative nephrotoxicity (elevated creatinine/BUN), ototoxicity (bilateral high-frequency tinnitus/hearing loss), peripheral sensory neuropathy. Rare/Severe: Acute renal tubular necrosis, severe myelosuppression, and anaphylactoid reactions.
🛡️ Safety Warnings
Black Box Warning: Cumulative, dose-dependent nephrotoxicity; ensure vigorous hydration and diuresis. Black Box Warning: Ototoxicity and peripheral neuropathy. Monitor serum creatinine, BUN, creatinine clearance, magnesium, and audiometry prior to each cycle. Contraindicated in pre-existing renal impairment, hearing impairment, or bone marrow depression.
Jan Aushadhi Products containing Cisplatin
Found 2 generic formulation(s) containing this active ingredient.
Cisplatin Injection 10 mg per10ml
Cisplatin Injection (10mg/10ml, 50mg/50ml) is a first-generation platinum coordination complex antineoplastic agent on the WHO Model List of Essential Medicines. It forms intrastrand and interstrand crosslinks with DNA purine bases (predominantly guanine-guanine), distorting the DNA helix, halting replication and transcription, and triggering p53-dependent apoptotic cell death. Indicated for treatment of metastatic testicular cancer, advanced ovarian cancer, advanced bladder cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and cervical cancer.
Cisplatin Injection 50mg per 50ml
Cisplatin Injection (10mg/10ml, 50mg/50ml) is a first-generation platinum coordination complex antineoplastic agent on the WHO Model List of Essential Medicines. It forms intrastrand and interstrand crosslinks with DNA purine bases (predominantly guanine-guanine), distorting the DNA helix, halting replication and transcription, and triggering p53-dependent apoptotic cell death. Indicated for treatment of metastatic testicular cancer, advanced ovarian cancer, advanced bladder cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and cervical cancer.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Cisplatin.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Cisplatin Injection 10 mg per10ml | Vial | ₹32.81 | PLATIN, Kemoplat, Cytoplatin, Cisplat | ₹5.21 | N/A |
| Cisplatin Injection 50mg per 50ml | Vial | ₹160.88 | PLATIN, KEMOPLAT, Cytoplatin | ₹5.88 | N/A |
Frequently Asked Questions (FAQ)
Get answers to common queries about Cisplatin generics.