Bicalutamide

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.

🧴 Clinical Application

Take orally 50 mg once daily at the same time each day (with or without food) with a glass of water, in combination with an LHRH analogue. Initiate bicalutamide at least 3 days prior to the first LHRH agonist injection to block symptomatic "testosterone flare".

⚠️ Side Effects

Common: Hot flashes, gynecomastia, breast pain/tenderness, asthenia, back pain, constipation, peripheral edema. Rare/Severe: Severe drug-induced hepatotoxicity / hepatic failure, interstitial lung disease, and cardiac failure.

🛡️ Safety Warnings

Monitor liver function tests (ALT, AST, bilirubin) prior to therapy, every month for the first 4 months, and periodically thereafter; discontinue immediately if transaminases exceed 2× ULN with jaundice. Discontinue if unexplained pulmonary symptoms (dyspnea, cough) occur.