TabletsClinical Overview
Olanzapine is a second-generation atypical thienobenzodiazepine antipsychotic and mood stabilizer on the WHO Model List of Essential Medicines. It acts by antagonizing serotonin 5-HT2A and dopamine D2 receptors, with high affinity for 5-HT2C, H1, and alpha-1 receptors, delivering potent antipsychotic efficacy with low extrapyramidal liability. Indicated for schizophrenia, acute manic or mixed episodes in bipolar I disorder, maintenance in bipolar disorder, and treatment-resistant depression (in combination with fluoxetine).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily, preferably in the evening or at bedtime with water, with or without food. Swallow whole. Regularly monitor body weight, waist circumference, fasting blood glucose, and lipid panel. Taper gradually when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, marked weight gain, increased appetite, dizziness, dry mouth, constipation, peripheral edema. Rare/Severe: Boxed warning: Increased mortality in elderly dementia patients; severe metabolic syndrome (diabetic ketoacidosis, hyperosmolar coma), neuroleptic malignant syndrome (NMS), tardive dyskinesia, and DRESS syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for elderly patients with dementia-related psychosis. High risk of substantial weight gain, hyperlipidemia, and new-onset type 2 diabetes mellitus; metabolic monitoring is mandatory. Contraindicated in patients with known narrow-angle glaucoma.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Olanzapine Tablets 5mg
Olanzapine is a second-generation atypical thienobenzodiazepine antipsychotic and mood stabilizer on the WHO Model List of Essential Medicines. It acts by antagonizing serotonin 5-HT2A and dopamine D2 receptors, with high affinity for 5-HT2C, H1, and alpha-1 receptors, delivering potent antipsychotic efficacy with low extrapyramidal liability. Indicated for schizophrenia, acute manic or mixed episodes in bipolar I disorder, maintenance in bipolar disorder, and treatment-resistant depression (in combination with fluoxetine).
Olanzapine 5mg + Fluoxetine 20mg Tablets
Fluoxetine Hydrochloride is a prototype selective serotonin reuptake inhibitor (SSRI) on the WHO Model List of Essential Medicines. It blocks the presynaptic serotonin transporter (SERT) and possesses a long elimination half-life (1-3 days for parent drug, 7-15 days for active norfluoxetine), providing a built-in buffer against abrupt discontinuation syndrome. Also displays mild 5-HT2C antagonism, contributing to energizing/activating effects. Indicated for major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder.