DropsClinical Overview
Nepafenac (0.1% w/v eye drops) is an ophthalmic non-steroidal anti-inflammatory prodrug. It penetrates the cornea rapidly, where intraocular hydrolases convert it into amfenac, a potent cyclooxygenase (COX-1 and COX-2) inhibitor, suppressing prostaglandin synthesis in the anterior and posterior chambers. Indicated for the prevention and treatment of post-operative ocular pain and inflammation, and reduction in the risk of macular edema associated with cataract surgery in diabetic patients.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Shake bottle well. Instill one drop into the operated eye(s) 3 times daily starting 1 day before cataract surgery, on the day of surgery, and continuing for 2 weeks post-operatively.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Foreign body sensation, punctate keratitis, sticky sensation in eye, blurred vision. Rare/Severe: Corneal melt, corneal thinning, persistent epithelial defects, and corneal perforation.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Patients with complicated ocular surgeries, corneal denervation, diabetes, or rheumatoid arthritis are at heightened risk of severe corneal adverse reactions (corneal melts/perforation); stop immediately if epithelial breakdown occurs.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or ophthalmic treatment recommendations. Always consult a registered ophthalmologist or ENT specialist before initiating, changing, or instilling any ophthalmic or otic medication.