TabletsClinical Overview
Letrozole Tablets (2.5mg) is an oral non-steroidal third-generation aromatase inhibitor on the WHO Model List of Essential Medicines. It competitively binds to the heme group of the CYP19A1 aromatase enzyme, inhibiting the peripheral conversion of androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) in adipose and peripheral tissues by >98.8%. In postmenopausal women, peripheral aromatization is the primary estrogen source. Indicated for adjuvant and first-line treatment of postmenopausal women with hormone receptor-positive (HR+) breast cancer, extended adjuvant therapy after 5 years of tamoxifen, and off-label ovulation induction in polycystic ovary syndrome (PCOS).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 2.5 mg once daily with a glass of water, with or without food. Standard adjuvant duration is 5 years (or extended to 10 years).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Hot flashes, arthralgia (joint pain), bone stiffness, fatigue, osteoporosis, hypercholesterolemia, night sweats. Rare/Severe: Bone fractures, ischemic cardiac events, and hypercalcemia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in premenopausal women (ineffective as monotherapy due to intact ovarian estrogen production). Accelerates bone mineral density loss and fracture risk; baseline and annual DEXA bone scans and calcium/vitamin D supplementation are strongly recommended.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, oncological diagnosis, or chemotherapy protocol guidance. Cancer therapies require specialized administration under the direct supervision of a registered medical oncologist in an accredited healthcare facility.