OintmentClinical Overview
Acyclovir (3% w/w ophthalmic ointment) is a synthetic purine nucleoside analogue antiviral on the WHO Model List of Essential Medicines. It is selectively converted by viral thymidine kinase into acyclovir monophosphate, which is subsequently converted to triphosphate, competitively inhibiting herpes simplex DNA polymerase and halting viral replication. Indicated for the treatment of herpes simplex keratitis (dendritic corneal ulcers).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Apply a 1 cm ribbon of ointment inside the lower conjunctival sac 5 times daily (approximately every 4 hours during waking hours). Continue treatment for at least 3 days after complete corneal re-epithelialization.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Transient mild stinging immediately after application, superficial punctate keratopathy, blurred vision. Rare/Severe: Allergic blepharitis, follicular conjunctivitis, and corneal stromal scarring.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Do not discontinue prematurely; continue for at least 3 days following complete ulcer healing. Corticosteroid eye drops are strictly contraindicated during active epithelial dendritic keratitis as they cause amoeboid geographic ulcers and corneal perforation. Avoid contact lenses.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or ophthalmic treatment recommendations. Always consult a registered ophthalmologist or ENT specialist before initiating, changing, or instilling any ophthalmic or otic medication.