TabletsClinical Overview
Flunarizine is a difluorinated piperazine derivative that acts as a selective, long-acting calcium channel blocker with additional antihistaminic, dopamine D2-blocking, and antiserotonergic actions. It prevents cellular calcium overload under ischemic and hyper-excitable conditions in cerebral neurons without altering normal myocardial or vascular tone. Indicated for migraine prophylaxis in patients with frequent severe attacks, vestibular vertigo, and refractory partial seizures (adjunct).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily strictly at bedtime with water, with or without food. Bedtime dosing manages daytime sedation. Initial therapy should be evaluated after 6 to 8 weeks.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, fatigue, increased appetite, weight gain, depression. Rare/Severe: Flunarizine-induced parkinsonian extrapyramidal symptoms, severe clinical depression with suicidal ideation, and tardive dyskinesia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in patients with depressive illness, pre-existing Parkinson's disease, or other extrapyramidal movement disorders. Treatment should not exceed 6 months continuously without a treatment holiday to avoid drug-induced parkinsonism. Avoid driving.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Flunarizine Tablets 5 mg
Flunarizine is a difluorinated piperazine derivative that acts as a selective, long-acting calcium channel blocker with additional antihistaminic, dopamine D2-blocking, and antiserotonergic actions. It prevents cellular calcium overload under ischemic and hyper-excitable conditions in cerebral neurons without altering normal myocardial or vascular tone. Indicated for migraine prophylaxis in patients with frequent severe attacks, vestibular vertigo, and refractory partial seizures (adjunct).
Propranolol Hydrochloride 40mg Sustained Release) + Flunarizine Dihydrochloride 10mg Tablets
Beta-adrenergic receptor antagonist (cardioselective beta-1 blocker, non-selective beta blocker, or third-generation vasodilating beta-blocker with alpha-blockade or nitric oxide release) on the WHO Model List of Essential Medicines. It competitively blocks adrenergic stimulation, reducing heart rate, myocardial contractility, cardiac output, and renin release. Indicated for hypertension, stable angina pectoris, heart failure, cardiac arrhythmias, and post-myocardial infarction secondary prevention.